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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
37.88
Human Site:
S249
Identified Species:
55.56
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Chimpanzee
Pan troglodytes
XP_509931
527
59578
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
S252
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Dog
Lupus familis
XP_851216
527
59504
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Rat
Rattus norvegicus
XP_216727
527
59187
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
S257
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Chicken
Gallus gallus
Q5ZKQ6
527
59609
A249
F
P
P
T
E
P
S
A
T
T
R
A
F
Y
G
Frog
Xenopus laevis
NP_001083783
527
59670
S249
F
P
P
T
E
P
S
S
T
T
R
A
Y
Y
G
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
S249
F
P
P
T
E
P
S
S
F
T
R
A
Y
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
N248
F
P
P
A
E
P
A
N
S
S
R
A
F
F
G
Honey Bee
Apis mellifera
XP_001120791
454
52119
N190
K
S
S
I
V
I
V
N
G
N
F
Q
E
G
V
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
S244
E
V
T
R
K
E
L
S
S
N
E
N
W
F
G
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
N229
T
T
R
S
Y
F
G
N
L
N
F
F
G
G
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
E252
F
P
P
L
E
D
R
E
A
S
V
S
L
L
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
E353
L
P
P
G
E
R
R
E
I
T
L
E
T
I
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
86.6
100
86.6
N.A.
53.3
0
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
93.3
6.6
40
13.3
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
26.6
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
40
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
7
7
7
0
0
69
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% D
% Glu:
7
0
0
0
82
7
0
13
0
0
7
7
7
0
0
% E
% Phe:
75
0
0
0
0
7
0
0
7
0
13
7
13
19
0
% F
% Gly:
0
0
0
7
0
0
7
0
7
0
0
0
7
13
82
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
7
0
0
7
0
0
0
0
7
0
% I
% Lys:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
0
0
7
0
0
7
0
7
0
7
0
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
19
0
19
0
7
0
0
0
% N
% Pro:
0
82
82
0
0
69
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% Q
% Arg:
0
0
7
7
0
7
13
0
0
0
69
0
0
0
0
% R
% Ser:
0
7
7
7
0
0
63
63
13
13
0
7
0
0
0
% S
% Thr:
7
7
7
63
0
0
0
0
57
69
0
0
7
0
0
% T
% Val:
0
7
0
0
7
0
7
0
0
0
7
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
57
57
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _